Propranolol is a Beta-blocker used in the management of hypertension, angina, tremors, etc.
Salmeterol is a beta-2 agonist bronchodilator used for the management of asthma airway narrowing, shortness of breath, wheezing, congestion, etc.
The concomitant use of both Propranolol and Salmeterol can lead to a major drug interaction. Propranolol, as a Beta-blocker, antagonizes the effect of Salmeterol as a beta-2 adrenergic bronchodilator. This can precipitate acute, life-threatening bronchospasm in patients with asthma or other obstructive airway diseases (COPD). Propranolol blocks beta-2 adrenergic receptors which leads to increased airway resistance and reduced bronchodilation.
This is considered a major drug interaction in which an alternative is strongly advised.
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