Drug Interaction between Bisacodyl and Furosemide

Bisacodyl is a stimulant laxative which causes bowel movement in the small intestine and colon, also, alters water and electrolyte levels to further enhance the laxative effect.
Furosemide is a loop diuretic used for managing fluid retention (edema) in cases of congestive heart failure, liver disease or kidney disease.

The concomitant use of both Bisacodyl and Furosemide can lead to a moderate drug interaction. This is because Bisacodyl, as a laxative, can cause significant losses of fluid and electrolytes, including sodium, potassium, magnesium and zinc. These electrolytes losses may potentiate the pharmacologic effects of Furosemide, as a diuretic. This can lead to signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, lethargy, muscle cramps, decreased urination, postural hypotension, and tachycardia.

This is considered a major drug interaction in which close monitoring, especially K+, is strongly advised.

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