Drug Interaction between Carbamazepine and Gabapentin

Carbamazepine is an anti-convulsant that decreases nerve impulse transmission. Hence, it is used for the management of partial, tonic-clonic, mixed seizures. It is also used for the management of certain types of nerve pains like trigeminal neuralgia and glossopharyngeal neuralgia.
Gabapentin is an anticonvulsant drug used in the management of epilepsy and seizures. It is also used in managing pains with nerve origins.

The concomitant use of both Carbamazepine and Gabapentin can lead to a moderate drug interaction. This is because Carbamazepine can additively or synergistically increase the central nervous system (CNS) and respiratory-depressant effects of other CNS depressing drugs like Gabapentin.

This is considered a moderate drug interaction in which close monitoring or dosage titration is strongly advised. Also, patient should be advised to avoid activities requiring mental alertness and motor coordination like driving or operating heavy equipments.

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