Drug Interaction between Ciprofloxacin and Dexamethasone

Ciprofloxacin is a fluoroquinolone antibiotic agent used for the treatment of bacterial infections.
Dexamethasone is a corticosteroid used in the management of allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders, etc by preventing the release of inflammation substances.

The concomitant use of both Ciprofloxacin and Dexamethasone can lead to a major drug interaction. This is because fluoroquinolone (Ciprofloxacin) has been reported to potentiate the risk of tendinitis and tendon rupture in patients on corticosteroids (Dexamethasone). The mechanism is largely unknown. Tendinitis and tendon rupture involving the Achilles tendon and some cases involving the rotator cuff (the shoulder), the hand, the biceps, and the thumb have also been reported. Surgical repair is recommended, or else, it may result in disability. Tendon rupture can still occur several months after completion of fluoroquinolone therapy.

This is considered a major drug interaction in which an alternative is strongly advised.

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