Drug Interaction between Ibuprofen and Prednisone

Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug) used as an analgesic, antipyretic and antiinflammatory agent.
Prednisone is a corticosteroid used for the treatment of conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders.

The concomitant use of both drugs can lead to a moderate drug interaction. This is because Prednisone, as a corticosteroid, can increase the potential for serious gastrointestinal (GI) toxicity, including inflammation, bleeding, ulceration, and perforation when combined with Ibuprofen, as an NSAID. Studies reveal that oral corticosteroid can double the estimated relative risk for peptic ulcer disease and GI hemorrhage. Some studies have also suggested that the primary effect of corticosteroids in this interaction is to delay healing of erosions caused by NSAIDs.

This is considered a moderate drug interaction in which an alternative is strongly advised, else, very close monitoring is needed.

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