Drug Interaction between Ibuprofen and Warfarin

Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug) used as an analgesic, antipyretic and antiinflammatory agent.
Warfarin is a coumarin anticoagulant used for the treatment of blood clots in cases of deep vein thrombosis or pulmonary embolism. It is also employed in the prevention of thrombosis in high risk patients like stroke, atrial fibrillation, heart attack, etc.

The concomitant use of both Ibuprofen and Warfarin can lead to a major drug interaction. This is because NSAIDs like Ibuprofen interfere with platelet adhesion and aggregation due to COx inhibition which would eventually potentiate the hypoprothrombinemic effect and bleeding risks when combined with Warfarin.

This is considered a major drug interaction in which close monitoring and frequent checking of INR (International Normalised Ratio) is advised.

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